RT Journal Article
SR Electronic
T1 Degree and site of chromosomal instability define its oncogenic potential
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 638460
DO 10.1101/638460
A1 W.H.M. Hoevenaar
A1 A. Janssen
A1 A.I. Quirindongo
A1 H. Ma
A1 S. Klaasen
A1 A. Teixeira
A1 G.J.A. Offerhaus
A1 R.H. Medema
A1 N. Jelluma
A1 G.J.P.L. Kops
YR 2019
UL http://biorxiv.org/content/early/2019/09/12/638460.abstract
AB Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor formation have not unequivocally emerged from animal studies and are thus still unclear. CIN can both promote and suppress tumorigenesis, but variances in mechanisms and timings of CIN induction in different oncogenic backgrounds and associated tissues limit interpretation of the contributions of CIN. Using a novel conditional mouse model for diverse degrees of CIN, we find that a particular range is sufficient to drive very early onset spontaneous adenoma formation in the intestine, showing that CIN can act as a much more potent oncogenic driver than was previously reported. In mice predisposed to intestinal cancer (ApcMin/+), moderate but not low CIN causes a remarkable increase in adenoma burden in the entire intestinal tract, especially in the distal colon, more closely modelling human disease. Strikingly, high levels of CIN promote adenoma formation in the distal colon even more than moderate CIN does, but have no effect in the small intestine. Our results thus show that CIN can be potently oncogenic, but that certain levels of CIN can have contrasting effects in distinct tissues.