TY - JOUR T1 - Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head JF - bioRxiv DO - 10.1101/770917 SP - 770917 AU - Yuejiao Jin AU - Xiaofei Wang AU - Sylvi Febriana Rachmawati Irnadiastputri AU - Rosmin Elsa Mohan AU - Tin Aung AU - Shamira A. Perera AU - Craig Boote AU - Jost B. Jonas AU - Leopold Schmetterer AU - Michaël J.A. Girard Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/09/16/770917.abstract N2 - Purpose To study the effect of changing heart rate on the ocular pulse and the dynamic biomechanical behaviour of the optic nerve head (ONH) using a comprehensive mathematical model.Methods In a finite element model of a healthy eye, a biphasic choroid consisted of a solid phase with connective tissues and a fluid phase with blood, and the lamina cribrosa (LC) was viscoelastic as characterized by a stress-relaxation test. We applied arterial pressures at 18 ocular entry sites (posterior ciliary arteries) and venous pressures at four exit sites (vortex veins). In the model, the heart rate was varied from 60 bpm to 120 bpm (increment: 20 bpm). We assessed the ocular pulse amplitude (OPA), pulse volume, ONH deformations and the dynamic modulus of the LC at different heart rates.Results With an increasing heart rate, the OPA decreased by 0.04 mmHg for every 10 bpm increase in heart rate. The ocular pulse volume decreased linearly by 0.13 µL for every 10 bpm increase in heart rate. The storage modulus and the loss modulus of the LC increased by 0.014 MPa and 0.04 MPa, respectively, for every 10 bpm increase in heart rate.conclusions In our model, the OPA, pulse volume, and ONH deformations decreased with an increasing heart rate, while the LC became stiffer. The effects of blood pressure / heart rate changes on ONH stiffening may be of interest for glaucoma pathology.Support Singapore Ministry of Education, Academic Research Fund, Tier 2 (R-397-000-280-112).Commercial relationship None ER -