RT Journal Article
SR Electronic
T1 Reliability of Mismatch Negativity Event-Related Potentials in a Multisite, Traveling Subjects Study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 768408
DO 10.1101/768408
A1 Brian J. Roach
A1 Ricardo E. Carrión
A1 Holly K. Hamilton
A1 Peter Bachman
A1 Aysenil Belger
A1 Erica Duncan
A1 Jason Johannesen
A1 Gregory A. Light
A1 Margaret Niznikiewicz
A1 Jean Addington
A1 Carrie E. Bearden
A1 Kristin S. Cadenhead
A1 Tyrone D. Cannon
A1 Barbara A. Cornblatt
A1 Thomas H. McGlashan
A1 Diana O. Perkins
A1 Larry Seidman
A1 Ming Tsuang
A1 Elaine F. Walker
A1 Scott W. Woods
A1 Daniel H. Mathalon
YR 2019
UL http://biorxiv.org/content/early/2019/09/18/768408.abstract
AB Objective Mismatch negativity (MMN) is an auditory event-related potential (ERP) used to study schizophrenia and psychosis risk. MMN reliability from a multisite, traveling subjects study was compared using different ERP referencing, averaging, and scoring techniques.Methods Reliability of frequency, duration, and double (frequency+duration) MMN was determined from eight traveling subjects, tested on two occasions at eight EEG laboratory sites. Deviant-specific variance components were estimated for MMN peak amplitude and latency measures using different ERP processing methods. Generalizability (G) coefficients were calculated using two-facet (site, occasion), fully-crossed models and single-facet (occasion) models within each laboratory to assess MMN reliability.Results G-coefficients calculated from two-facet models indicated fair (0.4<G<=0.6) duration MMN reliability at electrode Fz, but poor (G<0.4) double and frequency MMN reliability. Single-facet G-coefficients averaged across laboratory resulted in improved reliability (G>0.5). Reliability of MMN amplitude was greater than latency, and reliability with mastoid referencing significantly outperformed nose-referencing.Conclusions EEG preprocessing methods have a significant impact on the reliability of MMN amplitude. Within site MMN reliability can be excellent, consistent with prior single site studies.Significance With standardized data collection and ERP processing, MMN can be reliably obtained in multisite studies, providing larger samples sizes within rare patient groups.