TY - JOUR T1 - PHENOTYPIC AND GENETIC CORRELATION BETWEEN SLEEP, BEHAVIOR, AND MACROSCALE CORTICAL GREY MATTER JF - bioRxiv DO - 10.1101/772681 SP - 772681 AU - Masoud Tahmasian AU - Fateme Samea AU - Habibolah Khazaie AU - Mojtaba Zarei AU - Shahrzad Kharabian AU - Felix Hoffstaedter AU - Julia A. Camilleri AU - Peter Kochunov AU - B.T. Thomas Yeo AU - Simon B. Eickhoff AU - Sofie L. Valk Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/09/18/772681.abstract N2 - Humans need about 7 to 9 hours of sleep per night. Sleep habits are heritable, associated with brain function and structure, and intrinsically related to well-being, mental and physical health. This raises the question whether associations between sleep, mental and physical health can be attributed to a shared macroscale neurobiology.Combining neuroimaging and behavioral genetic approaches in two independent large-scale datasets (n=1887) we demonstrate phenotypic and genetic correspondence between sleep, intelligence, and BMI. Sleep was associated with local thickness variation in frontal, temporal, and occipital cortices. Using a comprehensive multivariate approach, we identified two robust latent components highlighting the interdigitation of sleep, intelligence, BMI, and depression and their shared relation to regions in unimodal and heteromodal association cortices. Latent relationships were heritable and driven by shared additive genetic factors. These observations provide a system-level perspective on the interrelation of sleep, mental, and physical conditions, anchored in grey-matter neuroanatomy. ER -