RT Journal Article SR Electronic T1 A Quantitative Tractography Study into the Connectivity, Segmentation and Laterality of the Human Inferior Longitudinal Fasciculus JF bioRxiv FD Cold Spring Harbor Laboratory SP 291625 DO 10.1101/291625 A1 Sandip S Panesar A1 Yeh Fang-Cheng A1 Timothée Jacquesson A1 William Hula A1 C Fernandez-Miranda Juan YR 2018 UL http://biorxiv.org/content/early/2018/04/07/291625.abstract AB The human inferior longitudinal fasciculus (ILF) is a ventral, temporo-occipital association tract. Though described in early neuroanatomical works, its existence was later questioned. Application of in vivo tractography to the neuroanatomical study of the ILF has generally confirmed its existence, however consensus is lacking regarding its subdivision, laterality and connectivity. Further, there is a paucity of detailed neuroanatomic data pertaining to the exact anatomy of the ILF. Generalized Q-Sampling imaging (GQI) is a non-tensor tractographic modality permitting high resolution imaging of white-matter structures. As it is a non-tensor modality, it permits visualization of crossing fibers and accurate delineation of close-proximity fiber-systems. We applied deterministic GQI tractography to data from 30 healthy subjects and a large-volume diffusion atlas, to delineate ILF anatomy. Post-mortem white matter dissection was also carried out in a cadaveric specimen for further validation. The ILF was found in all 60 hemispheres. At its occipital extremity, it demonstrated a trifurcated termination pattern which was used to separate the ILF into 3 distinct sub-fascicles: Dorsolateral, ventrolateral and ventromedial. These divisions were consistent across the subject set and within the atlas. We applied quantitative techniques to study connectivity strength of the ILF at its anterior and posterior extremities. Overall, the 3 sub-fascicles, and the whole ILF, demonstrated strong leftward-lateralized connectivity patterns. Leftward-lateralization was also found for ILF volumes across the subject set. Due to connective and volumetric leftward-dominance and ventral location, we postulate the ILFs role in the semantic system. Further, our results are in agreement with functional and lesion-based postulations pertaining to the ILFs role in facial recognition.NBLeft and Right hemispheric connections are demonstrated with a suffix _L or_RTlnfinferior temporal gyrusTMdmiddle temporal gyrusTSpsuperior temporal gyrusFufusiform gyrusol nfinferior occipital gyrusOMdmiddle occipital gyrusOSpsuperior occipital gyrusCalcalcarine gyrusCuncuneusLinlingual gyrusAmamygdalaHipphippocampus