TY - JOUR T1 - Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon JF - bioRxiv DO - 10.1101/774273 SP - 774273 AU - Gabriel Tarrason Risa AU - Fredrik Hurtig AU - Sian Bray AU - Anne E. Hafner AU - Lena Harker-Kirschneck AU - Peter Faull AU - Colin Davis AU - Dimitra Papatziamou AU - Delyan R. Mutavchiev AU - Catherine Fan AU - Leticia Meneguello AU - Andre Arashiro Pulschen AU - Gautam Dey AU - Siân Culley AU - Mairi Kilkenny AU - Luca Pellegrini AU - Robertus A. M. de Bruin AU - Ricardo Henriques AU - Ambrosius P Snijders AU - Anđela Šarić AU - Ann-Christin Lindås AU - Nick Robinson AU - Buzz Baum Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/09/18/774273.abstract N2 - The archaeon Sulfolobus acidocaldarius is a relative of eukaryotes known to progress orderly through its cell division cycle despite lacking obvious CDK/cyclin homologues. Here, in exploring the mechanisms underpinning archaeal cell division cycle control, we show that the proteasome of S. acidocaldarius, like its eukaryotic counterpart, regulates the transition from the end of one cell division cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homologue CdvB as a key target of the proteasome, and show that state-dependent degradation of CdvB triggers archaeal cell division by allowing constriction of a CdvB1:CdvB2 ESCRT-III division ring. These findings suggest an ancient role for proteasome-mediated degradation in resetting the cell division cycle in both archaea and eukaryotes. ER -