PT  - JOURNAL ARTICLE
AU  - Evelien H.S. Schut
AU  - Alejandra Alonso
AU  - Steven Smits
AU  - Mehdi Khamassi
AU  - Anumita Samanta
AU  - Moritz Negwer
AU  - Nael Nadif Kasri
AU  - Irene Navarro Lobato
AU  - Lisa Genzel
TI  - The Object Space Task reveals a dissociation between semantic-like and episodic-like memory in a mouse model of Kleefstra Syndrome
AID  - 10.1101/781054
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 781054
4099  - http://biorxiv.org/content/early/2019/09/25/781054.short
4100  - http://biorxiv.org/content/early/2019/09/25/781054.full
AB  - Kleefstra syndrome is a disorder caused by a mutation in the EHMT1 gene characterized in humans by general developmental delay, mild to severe intellectual disability and autism. Here, we characterized semantic- and episodic-like memory in the Ehmt1+/- mouse model using the Object Space Task. We combined conventional behavioral analysis with automated analysis by deep-learning networks, a session-based computational learning model and a trial-based classifier. Ehmt1 +/- mice showed more anxiety-like features and generally explored objects less, but the difference decreased over time. Interestingly, when analyzing memory-specific exploration, Ehmt1 +/- show increased expression of semantic-like memory, but a deficit in episodic-like memory. A similar dissociation of semantic and episodic memory performance has been previously reported in humans with autism. Using our automatic classifier to differentiate between genotypes, we found that semantic-like memory features are better suited for classification than general exploration differences. Thus, detailed behavioral classification with the Object Space Task produced a more detailed behavioral phenotype of the Ehmt1 +/- mouse model.One Sentence Summary Ehmt1 +/- mice show decreased exploration and episodic-like memory but increased semantic-like memory In the Object Space Task. (143 of 150)