TY - JOUR T1 - Non-invasive stimulation of vagal afferents reduces gastric frequency JF - bioRxiv DO - 10.1101/773259 SP - 773259 AU - Vanessa Teckentrup AU - Sandra Neubert AU - João C. P. Santiago AU - Manfred Hallschmid AU - Martin Walter AU - Nils B. Kroemer Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/09/25/773259.abstract N2 - Metabolic feedback between the gut and the brain relayed via the vagus nerve contributes to energy homeostasis. We investigated in healthy adults whether non-invasive stimulation of vagal afferents impacts energy homeostasis via efferent effects on metabolism or digestion. In a randomized crossover design, we applied transcutaneous auricular vagus nerve stimulation (taVNS) while recording efferent metabolic effects using simultaneous electrogastrography (EGG) and indirect calorimetry. We found that taVNS reduced gastric myoelectric frequency (p =.008), but did not alter resting energy expenditure. We conclude that stimulating vagal afferents induces gastric slowing via vagal efferents without acutely affecting net energy expenditure at rest. Collectively, this highlights the potential of taVNS to modulate digestion by activating the dorsal vagal complex. Thus, taVNS-induced changes in gastric frequency are an important peripheral marker of brain stimulation effects. ER -