RT Journal Article
SR Electronic
T1 Convergent evidence for predispositonal effects of brain volume on alcohol consumption
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 299149
DO 10.1101/299149
A1 David AA Baranger
A1 Catherine H. Demers
A1 Nourhan M. Elsayed
A1 Annchen R. Knodt
A1 Spenser R. Radtke
A1 Aline Desmarais
A1 Lauren R. Few
A1 Arpana Agrawal
A1 Andrew C. Heath
A1 Deanna M. Barch
A1 Lindsay M. Squeglia
A1 Douglas E. Williamson
A1 Ahmad R. Hariri
A1 Ryan Bogdan
YR 2018
UL http://biorxiv.org/content/early/2018/04/13/299149.abstract
AB Alcohol consumption accounts for 5% of global disease burden. Using family and longitudinal data from three independent samples (Ns = 1,303, 897, & 223) spanning childhood/adolescence to middle age (ages 11-37), we identify replicable reductions in gray matter volumes of frontal gyri, which are genetically-conferred, and prospectively predict alcohol consumption and initiation of use. Further, gene expression in the frontal cortex is replicably associated with genetic risk for alcohol consumption. Frontal volume is a promising prognostic biomarker for alcohol consumption liability.