RT Journal Article
SR Electronic
T1 Chronic circadian disruption modulates breast cancer cell stemness and their immune microenvironment to drive metastasis in mice
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 777433
DO 10.1101/777433
A1 Eva Hadadi
A1 William Taylor
A1 Xiaomei Li
A1 Yetki Aslan
A1 Marthe Villote
A1 Julie Rivière
A1 Gaelle Duvallet
A1 Charlotte Auriau
A1 Sandrine Dulong
A1 Isabelle Raymond Letron
A1 Sylvain Provot
A1 Annelise Bennaceur-Griscelli
A1 Hervé Acloque
YR 2019
UL http://biorxiv.org/content/early/2019/09/26/777433.abstract
AB Breast cancer is the most common type and one of the major causes of cancer death in woman worldwide. Epidemiological studies have established a link between night shift work and increased cancer risk, suggesting that circadian disruption may interfere with carcinogenesis. We aim to shed light on the effect of chronic jetlag on mammary tumour development. Therefore, we used a mouse model of spontaneous mammary tumorigenesis that we exposed to chronic circadian disruption. We observed that circadian disruption significantly increases cancer cell dissemination and metastasis. It also enhances the stemness and tumour–initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. We finally showed that all these defects can be corrected by the use of a CXCR2 inhibitor. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.