PT  - JOURNAL ARTICLE
AU  - Hugh Pastoll
AU  - Derek Garden
AU  - Ioannis Papastathopoulos
AU  - Gülşen Sürmeli
AU  - Matthew F. Nolan
TI  - Inter- and intra-animal variation of integrative properties of stellate cells in the medial entorhinal cortex
AID  - 10.1101/678565
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 678565
4099  - http://biorxiv.org/content/early/2019/09/26/678565.short
4100  - http://biorxiv.org/content/early/2019/09/26/678565.full
AB  - Distinctions between cell types underpin organisational principles for nervous system function. Functional variation also exists between neurons of the same type. This is exemplified by correspondence between grid cell spatial scales and synaptic integrative properties of stellate cells (SCs) in the medial entorhinal cortex. However, we know little about how functional variability is structured either within or between individuals. Using ex-vivo patch-clamp recordings from up to 55 SCs per mouse, we find that integrative properties vary between mice and, in contrast to modularity of grid cell spatial scales, have a continuous dorsoventral organisation. Our results constrain mechanisms for modular grid firing and provide evidence for inter-animal phenotypic variability among neurons of the same type. We suggest that neuron type properties are tuned to circuit level set points that vary within and between animals.