TY - JOUR T1 - Cargo-free scaffold implant recruits metastatic cancer cells <em>via</em> lung-mimicking myeloid cell S100A8/A9 axis JF - bioRxiv DO - 10.1101/789974 SP - 789974 AU - Jing Wang AU - Matthew S. Hall AU - Grace G. Bushnell AU - Sophia M. Orbach AU - Ravi M. Raghani AU - Yining Zhang AU - Joseph T. Decker AU - Aaron H. Morris AU - Pridvi Kandagatla AU - Jacqueline S. Jeruss AU - Lonnie D. Shea Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/10/02/789974.abstract N2 - Pre-metastatic niches in distant tissue facilitate metastasis from the primary tumor. Cargo-free porous polymer scaffolds implanted in tumor-bearing mice act as synthetic metastatic niches recruiting metastasizing cancer cells. Herein, we investigated the mechanisms by which these implants attract cancer cells from circulation. Scaffolds attract cancer cells in part via S100A8/A9 secreted by Gr1+ myeloid cells in a mechanism that mimics lung metastasis. Further, cancer cells attracted to the scaffold have a lung-tropic gene expression signature regardless of their tissue of origin. The scaffold implant reduces metastasis to the lung suggesting otherwise lung-tropic cancer cells are diverted to the scaffold. The suppression of metastatic spread by the scaffold suggests this mechanism may be exploited for novel therapies, and may broadly influence the design of scaffold-based drug delivery system for anti-cancer therapy. ER -