PT  - JOURNAL ARTICLE
AU  - Sean M. Kelly
AU  - Ricardo Raudales
AU  - Miao He
AU  - Jannifer Lee
AU  - Yongsoo Kim
AU  - Leif G. Gibb
AU  - Priscilla Wu
AU  - Katie Matho
AU  - Pavel Osten
AU  - Ann M. Graybiel
AU  - Z. Josh Huang
TI  - Radial glial lineage progression and differential intermediate progenitor amplification underlie striatal compartments and circuit organization
AID  - 10.1101/244327
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 244327
4099  - http://biorxiv.org/content/early/2018/04/18/244327.short
4100  - http://biorxiv.org/content/early/2018/04/18/244327.full
AB  - The circuitry of the striatum is characterized by two organizational plans: the division into striosome and matrix compartments, thought to mediate evaluation and action, and the direct and indirect pathways, thought to promote or suppress behavior. The developmental origins of and relationships between these organizations are unknown, leaving a conceptual gap in understanding the cortico-basal ganglia system. Through genetic fate mapping, we demonstrate that striosome-matrix compartmentalization arises from a lineage program embedded in lateral ganglionic eminence radial glial progenitors mediating neurogenesis through two distinct types of intermediate progenitors (IPs). The early phase of this program produces striosomal spiny projection neurons (SPNs) through fate-restricted apical IPs (aIPSs) with limited capacity; the late phase produces matrix SPNs through fate-restricted basal IPs (bIPMs) with expanded capacity. Remarkably, direct and indirect pathway SPNs arise within both aIPS and bIPM pools, suggesting that striosome-matrix architecture is the fundamental organizational plan of basal ganglia circuitry organization.