RT Journal Article
SR Electronic
T1 Regional dynamics of fractal dimension of the LV endocardium from cine CT images
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 791731
DO 10.1101/791731
A1 Ashish Manohar
A1 Lorenzo Rossini
A1 Gabrielle Colvert
A1 Davis M. Vigneault
A1 Francisco Contijoch
A1 Marcus Y. Chen
A1 Juan Carlos del Alamo
A1 Elliot R. McVeigh
YR 2019
UL http://biorxiv.org/content/early/2019/10/03/791731.abstract
AB We present a method to leverage the high fidelity of CT to quantify regional left ventricular function using topography variation of the endocardium as a surrogate measure of strain. 4DCT images of 10 normal and 10 abnormal subjects, acquired with standard clinical protocols, were used. The topography of the endocardium was characterized by its regional values of fractal dimension (FD), computed using a box-counting algorithm developed in-house. The average FD in each of the 16 American Heart Association segments was calculated for each subject as a function of time over the cardiac cycle. The normal subjects showed a peak systolic percentage change in FD of 5.9% ± 2% in all free-wall segments, while the abnormal cohort experienced a change of 2% ± 1.2% (p < 0.00001). Septal segments, being smooth, did not undergo large changes in FD. Additionally, a principal component analysis was performed on the temporal profiles of FD to highlight the possibility for unsupervised classification of normal and abnormal function. The method developed is free from manual contouring and does not require any feature tracking or registration algorithms. The FD values in the free wall segments correlated well with radial strain and with endocardial regional shortening measurements.