PT  - JOURNAL ARTICLE
AU  - Ishtiaque Ahammad
TI  - Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents
AID  - 10.1101/303362
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 303362
4099  - http://biorxiv.org/content/early/2018/04/23/303362.short
4100  - http://biorxiv.org/content/early/2018/04/23/303362.full
AB  - Cocaine addiction is a global health problem that causes substantial damage to the health of addicted individuals around the world. Dopamine synthesizing neurons in the brain play a vital role in the addiction to cocaine. But the underlying molecular mechanisms that help cocaine exert its addictive effect have not been very well understood. Bioinformatics can be a useful tool in the attempt to broaden our understanding in this area. In the present study, Gene Set Enrichment Analysis (GSEA) was carried out on the upregulated genes from a dataset of Dopamine synthesizing neurons of post-mortem human brain of cocaine addicts. As a result of this analysis, 3 miRNAs have been identified as having significant influence on transcription of the upregulated genes. These 3 miRNAs hold therapeutic potential for the treatment of cocaine addiction.