RT Journal Article
SR Electronic
T1 Functional Balance between TCF21-Slug defines phenotypic plasticity and sub-classes in high-grade serous ovarian cancer
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 307934
DO 10.1101/307934
A1 Sagar S Varankar
A1 Swapnil C Kamble
A1 Avinash M Mali
A1 Madhuri M More
A1 Ancy Abraham
A1 Brijesh Kumar
A1 Kshama J. Pansare
A1 Nivedhitha J Narayanan
A1 Arijit Sen
A1 Rahul D Dhake
A1 Aparna N Joshi
A1 Divya Midha
A1 Mohit Kumar Jolly
A1 Ying Dong
A1 Judith A Clements
A1 Sharmila A Bapat
YR 2018
UL http://biorxiv.org/content/early/2018/04/25/307934.abstract
AB Cellular plasticity and transitional phenotypes add to complexities of cancer metastasis initiated by single cell epithelial to mesenchymal transition or cooperative cell migration (CCM). We identified novel regulatory cross-talks between Tcf21 and Slug in mediating phenotypic and migration plasticity in high-grade serous ovarian adenocarcinoma. Live imaging discerned CCM as being achieved either through rapid cell proliferation or sheet migration. Transitional states were enriched over the rigid epithelial or mesenchymal phenotypes under conditions of environmental stresses. The Tcf21-Slug interplay identified in HGSC tumors through effective stratification of subtypes also contributed to class-switching in response to disease progression or therapy. Our study effectively provides a framework for understanding the relevance of cellular plasticity in situ as a function of two transcription factors.