RT Journal Article
SR Electronic
T1 A mechanistic hydro-epidemiological model of liver fluke risk
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 307348
DO 10.1101/307348
A1 Ludovica Beltrame
A1 Toby Dunne
A1 Hannah Rose Vineer
A1 Josephine G. Walker
A1 Eric R. Morgan
A1 Peter Vickerman
A1 Catherine M. McCann
A1 Diana J.L. Williams
A1 Thorsten Wagener
YR 2018
UL http://biorxiv.org/content/early/2018/04/26/307348.abstract
AB The majority of existing models for predicting disease risk in response to climate change are empirical. These models exploit correlations between historical data, rather than explicitly describing relationships between cause and response variables. Therefore, they are unsuitable for capturing impacts beyond historically observed variability and cannot be employed to assess interventions. In this study, we integrate environmental and epidemiological processes into a new mechanistic model, taking the widespread parasitic disease of fasciolosis as an example. The model simulates environmental suitability for disease transmission, explicitly linking the parasite life-cycle to key weather-water-environment conditions. First, using epidemiological data, we show that the model can reproduce observed infection levels in time and space over two case studies in the UK. Second, to overcome data limitations, we propose a calibration approach based on Monte Carlo sampling and expert opinion, which allows constraint of the model in a process-based way, including a quantification of uncertainty. Finally, comparison with information from the literature and a widely-used empirical risk index shows that the simulated disease dynamics agree with what has been traditionally observed, and that the new model gives better insight into the time-space patterns of infection, which will be valuable for decision support.