PT  - JOURNAL ARTICLE
AU  - Olivier François
AU  - Séverine Liégeois
AU  - Benjamin Demaille
AU  - Flora Jay
TI  - Inference of population genetic structure from temporal samples of DNA
AID  - 10.1101/801324
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 801324
4099  - http://biorxiv.org/content/early/2019/10/15/801324.short
4100  - http://biorxiv.org/content/early/2019/10/15/801324.full
AB  - The recent years have seen a growing number of studies investigating evolutionary questions using ancient DNA techniques and temporal samples of DNA. To address these questions, one of the most frequently-used algorithm is based on principal component analysis (PCA). When PCA is applied to temporal samples, the sample dates are, however, ignored during analysis, which could lead to some misinterpretations of the results. Here we introduce a new factor analysis (FA) method for which individual scores are corrected for the effect of allele frequency drift through time. Based on a diffusion approximation, our approach approximates allele frequency drift in a random mating population by a Brownian process. Exact solutions for estimates of corrected factors are obtained, and a fast estimation algorithm is presented. We compared data representations obtained from the FA method with PCA and with PC projections in simulations of divergence and admixture scenarios. Then we applied FA with correction for temporal drift to study the evolution of hepatitis C virus in a patient infected by multiple strains, and to describe the population structure of ancient European samples.