PT  - JOURNAL ARTICLE
AU  - Marazzi, Lauren
AU  - Gainer-Dewar, Andrew
AU  - Vera-Licona, Paola
TI  - OCSANA+: Optimal Control and Simulation of Signaling Networks from Network Analysis
AID  - 10.1101/806315
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 806315
4099  - http://biorxiv.org/content/early/2019/10/16/806315.short
4100  - http://biorxiv.org/content/early/2019/10/16/806315.full
AB  - Summary OCSANA+ is a Cytoscape app for identifying driver nodes that control non-linear systems’ long-term dynamics, prioritizing combinations of interventions in large scale complex networks, and estimating the effects of node perturbations in signaling networks, all based on the analysis of the network’s structure. OCSANA+ includes an update to the previously introduced OCSANA (optimal combinations of interventions from network analysis) software tool with cutting-edge and rigorously tested algorithms, together with recently-developed structure-based control algorithms for non-linear systems and an algorithm for estimating the signal flow. All these algorithms are based on the network’s topology. OCSANA+ is implemented as a Cytoscape app to enable a straightforward user interface for running analyses and visualizing results.Availability and Implementation OCSANA+ app and its tutorial can be downloaded from https://veraliconaresearchgroup.github.io/OCSANA-Plus/. The source code is available in https://github.com/VeraLiconaResearchGroup/OCSANA-Plus SourceCode.