RT Journal Article
SR Electronic
T1 OCSANA+: Optimal Control and Simulation of Signaling Networks from Network Analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 806315
DO 10.1101/806315
A1 Lauren Marazzi
A1 Andrew Gainer-Dewar
A1 Paola Vera-Licona
YR 2019
UL http://biorxiv.org/content/early/2019/10/16/806315.abstract
AB Summary OCSANA+ is a Cytoscape app for identifying driver nodes that control non-linear systems’ long-term dynamics, prioritizing combinations of interventions in large scale complex networks, and estimating the effects of node perturbations in signaling networks, all based on the analysis of the network’s structure. OCSANA+ includes an update to the previously introduced OCSANA (optimal combinations of interventions from network analysis) software tool with cutting-edge and rigorously tested algorithms, together with recently-developed structure-based control algorithms for non-linear systems and an algorithm for estimating the signal flow. All these algorithms are based on the network’s topology. OCSANA+ is implemented as a Cytoscape app to enable a straightforward user interface for running analyses and visualizing results.Availability and Implementation OCSANA+ app and its tutorial can be downloaded from https://veraliconaresearchgroup.github.io/OCSANA-Plus/. The source code is available in https://github.com/VeraLiconaResearchGroup/OCSANA-Plus SourceCode.