RT Journal Article
SR Electronic
T1 The genetic architecture of human brainstem structures and their involvement in common brain disorders
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 811711
DO 10.1101/811711
A1 Torbjørn Elvsåshagen
A1 Shahram Bahrami
A1 Dennis van der Meer
A1 Ingrid Agartz
A1 Dag Alnæs
A1 Deanna M. Barch
A1 Ramona Baur-Streubel
A1 Alessandro Bertolino
A1 Mona K. Beyer
A1 Giuseppe Blasi
A1 Stefan Borgwardt
A1 Birgitte Boye
A1 Jan Buitelaar
A1 Erlend Bøen
A1 Elisabeth Gulowsen Celius
A1 Simon Cervenka
A1 Annette Conzelmann
A1 David Coynel
A1 Pasquale Di Carlo
A1 Srdjan Djurovic
A1 Sarah Eisenacher
A1 Thomas Espeseth
A1 Helena Fatouros-Bergman
A1 Lena Flyckt
A1 Barbara Franke
A1 Oleksandr Frei
A1 Barbara Gelao
A1 Hanne Flinstad Harbo
A1 Catharina A. Hartman
A1 Asta Håberg
A1 Dirk Heslenfeld
A1 Pieter Hoekstra
A1 Einar A. Høgestøl
A1 Rune Jonassen
A1 Erik G. Jönsson
A1 Karolinska Schizophrenia Project (KaSP) consortium
A1 Peter Kirsch
A1 Iwona Kłoszewska
A1 Trine Vik Lagerberg
A1 Nils Inge Landrø
A1 Stephanie Le Hellard
A1 Klaus-Peter Lesch
A1 Luigi A. Maglanoc
A1 Ulrik F. Malt
A1 Patrizia Mecocci
A1 Ingrid Melle
A1 Andreas Meyer-Lindenberg
A1 Torgeir Moberget
A1 Jan Egil Nordvik
A1 Lars Nyberg
A1 Kevin S. O’Connell
A1 Jaap Oosterlaan
A1 Marco Papalino
A1 Andreas Papassotiropoulos
A1 Paul Pauli
A1 Giulio Pergola
A1 Karin Persson
A1 Dominique de Quervain
A1 Andreas Reif
A1 Jarek Rokicki
A1 Daan van Rooij
A1 Alexey A. Shadrin
A1 André Schmidt
A1 Emanuel Schwarz
A1 Geir Selbæk
A1 Hilkka Soininen
A1 Piotr Sowa
A1 Vidar M. Steen
A1 Magda Tsolaki
A1 Bruno Vellas
A1 Lei Wang
A1 Eric Westman
A1 Georg Ziegler
A1 Mathias Zink
A1 Ole A. Andreassen
A1 Lars T. Westlye
A1 Tobias Kaufmann
YR 2019
UL http://biorxiv.org/content/early/2019/10/21/811711.abstract
AB Brainstem regions support critical bodily functions, yet their genetic architectures and involvement in brain disorders remain understudied. Here, we examined volumes of brainstem structures using magnetic resonance imaging in 43,353 individuals. In 27,034 genotyped healthy participants, we identified 16 genetic loci associated with whole brainstem volume and 10, 23, 3, and 9 loci associated with volumes of the midbrain, pons, superior cerebellar peduncle, and medulla oblongata, respectively. These loci were mapped to 305 genes, including genes linked to brainstem development and common brain disorders. We detected genetic overlap between the brainstem volumes and eight psychiatric and neurological disorders. Using imaging data from 16,319 additional individuals, we observed differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease. Together, our results provide new insights into the genetic underpinnings of brainstem structures and support their involvement in common brain disorders.