RT Journal Article
SR Electronic
T1 A proteomics-based systems genetics approach reveals environment-specific loci modulating protein co-expression and drought-related traits in maize
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 636514
DO 10.1101/636514
A1 Mélisande Blein-Nicolas
A1 Sandra Sylvia Negro
A1 Thierry Balliau
A1 Claude Welcker
A1 Llorenç Cabrera Bosquet
A1 Stéphane Dimitri Nicolas
A1 Alain Charcosset
A1 Michel Zivy
YR 2019
UL http://biorxiv.org/content/early/2019/10/22/636514.abstract
AB The evolution of maize yields under drought is of particular concern in the context of climate change and human population growth. To better understand the mechanisms associated with the genetic polymorphisms underlying the variations of traits related to drought tolerance, we used a systems genetics approach integrating high-throughput phenotypic, proteomics and genomics data acquired on 254 maize hybrids grown under two watering conditions. We show that water deficit, even mild, induced a strong proteome remodeling and a reprogramming of the genetic control of the abundance of many proteins. We identify close co-localizations between QTLs and pQTLs, thus highlighting environment-specific pleiotropic loci associated to the co-expression of drought-responsive proteins and to the variations of phenotypic traits. These findings bring several lines of evidence supporting candidate genes at many loci and provide novel insight into the molecular mechanisms of drought tolerance.