RT Journal Article
SR Electronic
T1 Fast gene set enrichment analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 060012
DO 10.1101/060012
A1 Gennady Korotkevich
A1 Vladimir Sukhov
A1 Alexey Sergushichev
YR 2019
UL http://biorxiv.org/content/early/2019/10/22/060012.abstract
AB Preranked gene set enrichment analysis (GSEA) is a widely used method for interpretation of gene expression data in terms of biological processes. Here we present FGSEA method that is able to estimate arbitrarily low GSEA P-values with a higher accuracy and much faster compared to other implementations. We also present a polynomial algorithm to calculate GSEA P-values exactly, which we use to practically confirm the accuracy of the method.