RT Journal Article
SR Electronic
T1 Emergence of opposite neurons in a firing-rate model of multisensory integration
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 814483
DO 10.1101/814483
A1 Ho Yin Chau
A1 Wen-Hao Zhang
A1 Tai Sing Lee
YR 2019
UL http://biorxiv.org/content/early/2019/10/22/814483.abstract
AB Opposite neurons, found in macaque dorsal medial superior temporal (MSTd) and ventral intraparietal (VIP) areas, combine visual and vestibular cues of self-motion in opposite ways. A neural circuit recently proposed utilizes opposite neurons to perform causal inference and decide whether the visual and vestibular cues in MSTd and VIP should be integrated or segregated. However, it is unclear how these opposite connections can be formed with biologically realistic learning rules. We propose a network model capable of learning these opposite neurons, using Hebbian and Anti-Hebbian learning rules. The learned neurons are topographically organized and have von Mises-shaped feedforward connections, with tuning properties characteristic of opposite neurons. Our purpose is two-fold: on the one hand, we provide a circuit-level mechanism that explains the properties and formation of opposite neurons; on the other hand, we present a way to extend current theories of multisensory integration to account for appropriate segregation of sensory cues.