RT Journal Article
SR Electronic
T1 Quantifying nerve decussation abnormalities in the optic chiasm
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 633347
DO 10.1101/633347
A1 Robert J. Puzniak
A1 Khazar Ahmadi
A1 Jörn Kaufmann
A1 Andre Gouws
A1 Antony B. Morland
A1 Franco Pestilli
A1 Michael B. Hoffmann
YR 2019
UL http://biorxiv.org/content/early/2019/10/23/633347.abstract
AB Objective The human optic chiasm comprises partially crossing optic nerve fibres. Here we used diffusion MRI (dMRI) for the in-vivo identification of the abnormally high proportion of crossing fibres found in the optic chiasm of people with albinism.Methods In 9 individuals with albinism and 8 controls high-resolution 3T dMRI data was acquired and analyzed with a set of methods for signal modeling [Diffusion Tensor (DT) and Constrained Spherical Deconvolution (CSD)], tractography, and streamline filtering (LiFE, COMMIT, and SIFT2). The number of crossing and non-crossing streamlines and their weights after filtering entered ROC-analyses to compare the discriminative power of the methods based on the area under the curve (AUC). The dMRI results were cross-validated with fMRI estimates of misrouting in a subset of 6 albinotic individuals.Results We detected significant group differences in chiasmal crossing for both unfiltered DT (p=0.014) and CSD tractograms (p=0.0009) also reflected by AUC measures (for DT and CSD: 0.61 and 0.75, respectively), underlining the discriminative power of the approach. Estimates of crossing strengths obtained with dMRI and fMRI were significantly correlated for CSD (R2=0.83, p=0.012). The results show that streamline filtering methods in combination with probabilistic tracking, both optimized for the data at hand, can improve the detection of crossing in the human optic chiasm.Conclusions Especially CSD-based tractography provides an efficient approach to detect structural abnormalities in the optic chiasm. The most realistic results were obtained with filtering methods with parameters optimized for the data at hand.Significance Our findings demonstrate a novel anatomy-driven approach for the individualized diagnostics of optic chiasm abnormalities.HighlightsDiffusion MRI is capable of detecting structural abnormalities of the optic chiasm.Quantification of crossing strength in optic chiasm is of promise for albinism diagnostics.Optic chiasm is a powerful test model for neuroimaging methods resolving crossing fibers.