PT  - JOURNAL ARTICLE
AU  - Lucas S Rodrigues
AU  - Luiz H da Silva Nali
AU  - Cibele O D Leal
AU  - Ester C Sabino
AU  - Eliana M Lacerda
AU  - Caroline C Kingdon
AU  - Luis Nacul
AU  - Camila M Romano
TI  - HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
AID  - 10.1101/693465
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 693465
4099  - http://biorxiv.org/content/early/2019/10/24/693465.short
4100  - http://biorxiv.org/content/early/2019/10/24/693465.full
AB  - Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS / MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed that immunological, metabolic and environmental factors play a role. It is well documented an increased activity of Human endogenous retroviruses (HERVs) from different families in autoimmune and neurological diseases, making these elements good candidates for biomarkers or even triggers for such diseases. Here the expression of Endogenous retroviruses K and W (HERV–K and HERV–W) was determined in blood from moderately and severely affected ME/CFS patients. HERV-K was overexpressed only in moderately affected individuals and HERV-W showed no difference. This is the first report about HERV-K differential expression in moderate ME/CFS.