RT Journal Article
SR Electronic
T1 Methyl-CpG2-binding protein 2 mediates overlapping mechanisms across brain disorders
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 819573
DO 10.1101/819573
A1 Bach, Snow
A1 Ryan, Niamh M.
A1 Guasoni, Paolo
A1 Corvin, Aiden
A1 Tropea, Daniela
YR 2019
UL http://biorxiv.org/content/early/2019/10/28/819573.abstract
AB Methyl-CpG binding protein 2 (MeCP2) is a chromatin-binding protein and a modulator of gene expression. Initially identified as an oncogene, MECP2 is now mostly associated to Rett Syndrome, a neurodevelopmental condition, though there is evidence of its influence in other brain disorders.We design a procedure that considers several binding properties of MeCP2 and we screen for potential targets across neurological and neuropsychiatric conditions.We find MeCP2 target genes associated to a range of disorders, including - among others-Alzheimer Disease, Autism, Attention Deficit Hyperactivity Disorder and Multiple Sclerosis. The analysis of biological mechanisms and pathways modulated by MeCP2’s target genes shows that such mechanisms are involved in three main processes: neuronal transmission, immuno-reactivity and development.These results suggest that similar symptoms present in different pathologies have a common molecular basis, and that treatments for one condition have potential applications to related disorders.ADAlzheimer’s DiseaseADHDAttention Deficit Hyperactivity DisorderALSAmyotrophic Lateral SclerosisASDAutism Spectrum DisorderAUCArea Under the CurveBDNFBrain-Derived Neurotrophic FactorCDLK4Cyclin-Dependant Kinase-Like 4CNVCopy Number VariantDADopamineGWASGenome-Wide Association StudyHTTHuntington’s DiseaseMDDMajor Depressive DisorderMeCP2Methyl-CpG Binding Protein 2MEF2CMyocyte Enhancer Factor 2CmiRNAMicro RNAMSMultiple SclerosisNDDNeurodevelopmentalOCDObsessive Compulsive DisorderPDParkinson’s DiseasePPIProtein-Protein InteractionPFMPosition Frequency MatrixPWMPosition Weight MatrixRTTRett SyndromeROCReceiver Operated CharacteristicsSCZSchizophreniaTFTranscription Factor