RT Journal Article
SR Electronic
T1 Continuity between koniocellular layers of dorsal lateral geniculate and inferior pulvinar nuclei in common marmosets
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 315598
DO 10.1101/315598
A1 Bing-Xing Huo
A1 Natalie Zeater
A1 Meng Kuan Lin
A1 Yeonsook S. Takahashi
A1 Mitsutoshi Hanada
A1 Jaimi Nagashima
A1 Brian C. Lee
A1 Ulrike Grünert
A1 Michael I. Miller
A1 Marcello G.P. Rosa
A1 Hideyuki Okano
A1 Paul R. Martin
A1 Partha P. Mitra
YR 2018
UL http://biorxiv.org/content/early/2018/05/07/315598.abstract
AB The koniocellular (K) layers of the dorsal lateral geniculate nucleus (LGN) and the calbindin-rich subdivisions of the inferior pulvinar nucleus are considered part of a thalamic matrix system which projects diffusely to superficial cortical layers. Activity in the matrix system is proposed to coordinate oscillatory activity in thalamocortical loops. Here we studied connections of LGN K layers and IPul in marmosets following injections of retrograde tracer, Fast Blue, in V1 and V2. We adopted a high-throughput neuro-histology pipeline, which enabled simultaneous brain region identification based on cytoarchitecture and fluorescent tracer localization. A computational routine was established to automatically cross-register fluorescent neurons to individual subdivisions of LGN and IPul. We found that both V1 and V2 receive inputs from K layers and IPul, whereas dominant outputs of magnocellular and parvocellular layers of LGN were to V1 only. Retrograde labeled cells in lateral division of IPul merged seamlessly into the retrograde labeled cells in K layers. We hypothesize that the K layers and IPul form a contiguous functional subdivision of the dorsal thalamic matrix.