RT Journal Article
SR Electronic
T1 Molecularly distinct astrocyte subpopulations spatially pattern the adult mouse brain
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 317503
DO 10.1101/317503
A1 Mykhailo Y. Batiuk
A1 Araks Martirosyan
A1 Thierry Voet
A1 Chris P. Ponting
A1 T. Grant Belgard
A1 Matthew G. Holt
YR 2018
UL http://biorxiv.org/content/early/2018/05/10/317503.abstract
AB Astrocytes are a numerous cell type of the central nervous system. They perform many important functions in synapse formation and maintenance, control of local homeostasis and modulation of synaptic transmission. However, the degree to which specialist astrocyte subtypes fulfil these specific tasks is currently unclear. Here we use single cell transcriptomics to demonstrate that astrocytes, even those lying within the same region of adult mouse brain, show distinct molecular and spatial profiles, with profound implications for local CNS functions, including axon guidance, synaptogenesis and synaptic transmission.