%0 Journal Article %A Zilu Zhou %A Chengzhong Ye %A Jingshu Wang %A Nancy R. Zhang %T Surface protein imputation from single cell transcriptomes by deep neural networks %D 2019 %R 10.1101/671180 %J bioRxiv %P 671180 %X While single cell RNA sequencing (scRNA-seq) is invaluable for studying cell populations, cell-surface proteins are often integral markers of cellular function and serve as primary targets for therapeutic intervention. Here we propose a transfer learning framework, single cell Transcriptome to Protein prediction with deep neural network (cTP-net), to impute surface protein abundances from scRNA-seq data by learning from existing single-cell multi-omic resources. %U https://www.biorxiv.org/content/biorxiv/early/2019/11/02/671180.full.pdf