TY - JOUR T1 - Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes JF - bioRxiv DO - 10.1101/588350 SP - 588350 AU - Aidan McGlinchey AU - Tim Sinioja AU - Santosh Lamichhane AU - Johanna Bodin AU - Heli Siljander AU - Alex M. Dickens AU - Dawei Geng AU - Cecilia Carlsson AU - Daniel Duberg AU - Jorma Ilonen AU - Suvi M. Virtanen AU - Hubert Dirven AU - Hanne Friis Berntsen AU - Karin Zimmer AU - Unni C. Nygaard AU - Matej Orešič AU - Mikael Knip AU - Tuulia Hyötyläinen Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/11/04/588350.abstract N2 - In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid-related and immune markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association was exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring. ER -