RT Journal Article
SR Electronic
T1 DEK influences the trade-off between growth and arrest via H2A.Z-nucleosomes in Arabidopsis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 829226
DO 10.1101/829226
A1 Anna Brestovitsky
A1 Daphne Ezer
A1 Sascha Waidmann
A1 Sarah L. Maslen
A1 Martin Balcerowicz
A1 Sandra Cortijo
A1 Varodom Charoensawan
A1 Claudia Martinho
A1 Daniela Rhodes
A1 Claudia Jonak
A1 Philip A Wigge
YR 2019
UL http://biorxiv.org/content/early/2019/11/04/829226.abstract
AB The decision of whether to grow and proliferate or to restrict growth and develop resilience to stress is a key biological trade-off. In plants, constitutive growth results in increased sensitivity to environmental stress1,2. The underlying mechanisms controlling this decision are however not well understood. We used temperature as a cue to discover regulators of this process in plants, as it both enhances growth and development rates within a specific range and is also a stress at extremes. We found that the conserved chromatin-associated protein DEK plays a central role in balancing the response between growth and arrest in Arabidopsis, and it does this via H2A.Z-nucleosomes. DEK target genes show two distinct categories of chromatin architecture based on the distribution of H2A.Z in +1 nucleosome and gene body, and these predict induction or repression by DEK. We show that these chromatin signatures of DEK target genes are conserved in human cells, suggesting that DEK may act through an evolutionarily conserved mechanism to control the balance between growth and arrest in plants and animals.