TY - JOUR T1 - Arterial smooth muscle cell PKD2 (TRPP1) channels control systemic blood pressure JF - bioRxiv DO - 10.1101/320200 SP - 320200 AU - Simon Bulley AU - Carlos Fernandez-Pena AU - Raquibul Hasan AU - M. Dennis Leo AU - Padmapriya Muralidharan AU - Charles E. Mackay AU - Kirk W. Evanson AU - Sarah K. Burris AU - Qian Wang AU - Korah P. Kuruvilla AU - Jonathan H. Jaggar Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/05/11/320200.abstract N2 - Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological blood pressure and contribute to hypertension in vivo. We generated the first inducible, smooth muscle-specific knockout for a TRP channel, namely for PKD2 (TRPP1), to investigate arterial myocyte and blood pressure regulation by this protein. Using this model, we show that intravascular pressure and α1-receptors activate PKD2 channels in arterial myocytes of different systemic organs. PKD2 channel activation in arterial myocytes leads to an inward Na+ current, membrane depolarization and vasoconstriction. Inducible, smooth muscle cell-specific PKD2 knockout lowers both physiological blood pressure and hypertension and prevents pathological arterial remodeling during hypertension. In summary, we show for the first time that arterial myocyte PKD2 channels control systemic blood pressure and targeting reduces high blood pressure. ER -