@article {Railo245381, author = {Henry Railo and Henri Olkoniemi and Enni Eeronheimo and Oona P{\"a}{\"a}kkonen and Juho Joutsa and Valtteri Kaasinen}, title = {Dopamine and eye movement control in Parkinson{\textquoteright}s disease: deficits in corollary discharge signals?}, elocation-id = {245381}, year = {2018}, doi = {10.1101/245381}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Movement in Parkinson{\textquoteright}s disease (PD) is fragmented, and the patients depend on visual information in their behavior. This suggests that the patients may have deficits in internally monitoring their own movements. Internal monitoring of movements is assumed to rely on corollary discharge signals that enable the brain to predict the sensory consequences of actions. We studied early-stage PD patients (N=14), and age-matched healthy control participants (N=14) to examine whether PD patients reveal deficits in updating their sensory representations after eye movements. The participants performed a double-saccade task where, in order to accurately fixate a second target, the participant must correct for the displacement caused by the first saccade. In line with previous reports, the patients had difficulties in fixating the second target when the eye movement was performed without visual guidance. Furthermore, the patients had difficulties in taking into account the error in the first saccade when making a saccade towards the second target, especially when eye movements were made towards the side with dominant motor symptoms. Across PD patients, the impairments in saccadic eye movements correlated with the integrity of the dopaminergic system as measured with [123I]FP-CIT SPECT: Patients with lower striatal (caudate, anterior putamen and posterior putamen) dopamine transporter binding made larger errors in saccades. This effect was strongest when patients made memory-guided saccades towards the second target. Our results provide tentative evidence that the motor deficits in PD may be partly accounted by deficits in internal monitoring of movements.}, URL = {https://www.biorxiv.org/content/early/2018/05/14/245381}, eprint = {https://www.biorxiv.org/content/early/2018/05/14/245381.full.pdf}, journal = {bioRxiv} }