TY - JOUR T1 - Prediction of multiple drug resistant pulmonary tuberculosis against drug sensitive pulmonary tuberculosis by CT nodular consolidation sign JF - bioRxiv DO - 10.1101/833954 SP - 833954 AU - Xi-Ling Huang AU - Aliaksandr Skrahin AU - Pu-Xuan Lu AU - Sofia Alexandru AU - Valeriu Crudu AU - Andrei Astrovko AU - Alena Skrahina AU - Jessica Taaffe AU - Michael Harris AU - Alyssa Long AU - Kurt Wollenberg AU - Eric Engle AU - Darrell E. Hurt AU - Irada Akhundova AU - Sharafat Ismayilov AU - Elcan Mammadbayov AU - Hagigat Gadirova AU - Rafik Abuzarov AU - Mehriban Seyfaddinova AU - Zaza Avaliani AU - Sergo Vashakidze AU - Natalia Shubladze AU - Ucha Nanava AU - Irina Strambu AU - Dragos Zaharia AU - Alexandru Muntean AU - Eugenia Ghita AU - Miron Bogdan AU - Roxana Mindru AU - Victor Spinu AU - Alexandra Sora AU - Catalina Ene AU - Eugene Sergueev AU - Valery Kirichenko AU - Vladzimir Lapitski AU - Eduard Snezhko AU - Vassili Kovalev AU - Alexander Tuzikov AU - Andrei Gabrielian AU - Alex Rosenthal AU - Michael Tartakovsky AU - Yi Xiang J Wang Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/11/07/833954.abstract N2 - Multidrug-resistant tuberculosis (mdrtb) refers to TB infection resistant to at least two most powerful anti-TB drugs, isoniazid and rifampincin. It has been estimated that globally 3.5% (which can be much higher in some regions) of newly diagnosed TB patients, and 20.5% of previously treated patients had mdrtb. Extensively drug-resistant TB (xdrtb) has resistance to rifampin and isoniazid, as well as to any member of the quinolone family and at least one of the second line injectable drugs: kanamycin, amikacin and capreomycin. xdrtb accounts for 4-20% of mdrtb. Early detection and targeted treatment are priorities for mdrtb/xdrtb control. The suspicion of mdr/xdr -pulmonary TB (mdrptb or xdrptb) by chest imaging shall suggest intensive diagnostic testing for mdrptb/xdrptb. We hypothesize that multiple nodular consolidation (NC) may serve one of the differentiators for separating dsptb vs mdrptb/xdrptb cases. For this study, mdrptb cases (n=310) and XDR-PTB cases (⋂=I58) were from the NIAID TB Portals Program (TBPP) <https://tbportals.niaid.nih.gov>. Drug sensitive pulmonary TB (dsptb) cases were from the TBPP collection (n=112) as well as the Shenzhen Center for Chronic Disease Control (n=111), Shenzhen, China, and we excluded patients with HIV(+) status. Our study shows NC, particularly multiple NCs, is more common in mdrptb than in dsptb, and more common in xdrptb than in mdrptb. For example, 2.24% of dsptb patients, 13.23% of mdrptb patients, and 20.89% of xdrptb patients, respectively, have NCs with diameter >= 10mm equal or more than 2 in number. ER -