TY - JOUR T1 - Dynamics of social representation in the mouse prefrontal cortex JF - bioRxiv DO - 10.1101/321182 SP - 321182 AU - Dana Rubi Levy AU - Tal Tamir AU - Maya Kaufman AU - Aharon Weissbrod AU - Elad Schneidman AU - Ofer Yizhar Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/05/14/321182.abstract N2 - The prefrontal cortex (PFC) plays an important role in regulating social functions in mammals, and impairments in this region have been linked with social dysfunction in psychiatric disorders. Yet little is known of how the PFC encodes social information and of how social representations may be altered in such disorders. Here, we show that neurons in the medial PFC (mPFC) of freely behaving mice preferentially respond to socially-relevant sensory cues. Population activity patterns in the mPFC differed considerably between social and nonsocial stimuli and underwent experience-dependent refinement. In Cntnap2 knockout mice, a genetic model of autism, both the categorization of sensory stimuli and the refinement of social representations were impaired. Noise levels in spontaneous population activity were higher in Cntnap2 mice, and correlated strongly with the degree to which social representations were disrupted. Our findings elucidate the encoding of social sensory cues in the mPFC, and provide an important link between altered prefrontal dynamics and autism-associated social dysfunction. ER -