RT Journal Article
SR Electronic
T1 Unravelling the genetic architecture of musical rhythm
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 836197
DO 10.1101/836197
A1 Maria Niarchou
A1 J. Fah Sathirapongsasuti
A1 Nori Jacoby
A1 Eamonn Bell
A1 Evonne McArthur
A1 Peter Straub
A1 The 23andMe Research Team
A1 J. Devin McAuley
A1 John A. Capra
A1 Fredrik Ullén
A1 Nicole Creanza
A1 Miriam A. Mosing
A1 David Hinds
A1 Lea K. Davis
A1 Reyna L. Gordon
YR 2019
UL http://biorxiv.org/content/early/2019/11/09/836197.abstract
AB While timing and rhythm-related phenotypes are heritable, the human genome variations underlying these traits are not yet well-understood. We conducted a genome-wide association study to identify common genetic variants associated with a self-reported musical rhythm phenotype in 606,825 individuals. Rhythm exhibited a highly polygenic architecture with sixty-eight loci reaching genome-wide significance (p<5×10−8) and SNP-based heritability of 13%-16%. Polygenic scores for rhythm predicted the presence of musician-related keywords in the BioVU electronic health record biobank. Genetic associations with rhythm were enriched for genes expressed in brain tissues. Genetic correlation analyses revealed shared genetic architecture with several traits relevant to cognition, emotion, health, and circadian rhythms, paving the way to a better understanding of the neurobiological pathways of musicality.