PT  - JOURNAL ARTICLE
AU  - Adilson Guilherme
AU  - David J Pedersen
AU  - Felipe Henriques
AU  - Alexander H. Bedard
AU  - Elizabeth Henchey
AU  - Mark Kelly
AU  - Kamal Rahmouni
AU  - Donald A. Morgan
AU  - Michael P Czech
TI  - Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis
AID  - 10.1101/324160
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 324160
4099  - http://biorxiv.org/content/early/2018/05/16/324160.short
4100  - http://biorxiv.org/content/early/2018/05/16/324160.full
AB  - White adipose tissue (WAT) secretes factors to communicate with other metabolic organs to maintain energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) causes expansion of sympathetic neurons within white adipose tissue (WAT) and the appearance of “beige” adipocytes. Here we report evidence that white adipocyte DNL activity is also coupled to neuronal regulation and thermogenesis in brown adipose tissue (BAT). Induced deletion of FASN in all adipocytes in mature mice (iAdFASNKO) enhanced sympathetic innervation and neuronal activity as well as UCP1 expression in both WAT and BAT. In contrast, selective ablation of FASN in brown adipocytes of mice (iUCP1FASNKO) failed to modulate sympathetic innervation and the thermogenic program in BAT. Surprisingly, DNL in brown adipocytes was also dispensable in maintaining euthermia when UCP1FASNKO mice were cold-exposed. These results indicate that DNL in white adipocytes influences long distance signaling to BAT, which can modify BAT sympathetic innervation and expression of genes involved in thermogenesis.