RT Journal Article
SR Electronic
T1 Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 324160
DO 10.1101/324160
A1 Adilson Guilherme
A1 David J Pedersen
A1 Felipe Henriques
A1 Alexander H. Bedard
A1 Elizabeth Henchey
A1 Mark Kelly
A1 Kamal Rahmouni
A1 Donald A. Morgan
A1 Michael P Czech
YR 2018
UL http://biorxiv.org/content/early/2018/05/16/324160.abstract
AB White adipose tissue (WAT) secretes factors to communicate with other metabolic organs to maintain energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) causes expansion of sympathetic neurons within white adipose tissue (WAT) and the appearance of “beige” adipocytes. Here we report evidence that white adipocyte DNL activity is also coupled to neuronal regulation and thermogenesis in brown adipose tissue (BAT). Induced deletion of FASN in all adipocytes in mature mice (iAdFASNKO) enhanced sympathetic innervation and neuronal activity as well as UCP1 expression in both WAT and BAT. In contrast, selective ablation of FASN in brown adipocytes of mice (iUCP1FASNKO) failed to modulate sympathetic innervation and the thermogenic program in BAT. Surprisingly, DNL in brown adipocytes was also dispensable in maintaining euthermia when UCP1FASNKO mice were cold-exposed. These results indicate that DNL in white adipocytes influences long distance signaling to BAT, which can modify BAT sympathetic innervation and expression of genes involved in thermogenesis.