RT Journal Article
SR Electronic
T1 Cerebellar neurodynamics during motor planning predict decision timing and outcome on single-trial level
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 833889
DO 10.1101/833889
A1 Qian Lin
A1 Magdalena Helmreich
A1 Friederike Schlumm
A1 Jennifer M. Li
A1 Drew N. Robson
A1 Florian Engert
A1 Alexander Schier
A1 Tobias Nöbauer
A1 Alipasha Vaziri
YR 2019
UL http://biorxiv.org/content/early/2019/11/11/833889.abstract
AB The neuronal basis of goal-directed behavior requires interaction of multiple separated brain regions. How subcortical regions and their interactions with brain-wide activity are involved in action selection is less understood. We have investigated this question by developing an assay based on whole-brain volumetric calcium imaging using light-field microscopy combined with an operant-conditioning task in larval zebrafish. We find global and recurring dynamics of brain states to exhibit pre-motor bifurcations towards mutually exclusive decision outcomes which arises from a spatially distributed network. Within this network the cerebellum shows a particularly strong pre-motor activity, predictive of both the timing and outcome of behavior up to ∼10 seconds before movement initiation. Furthermore, on the single-trial level, decision directions can be inferred from the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the decision time can be quantitatively predicted by the rate of bi-hemispheric population ramping activity. Our results point towards a cognitive role of the cerebellum and its importance in motor planning.