TY - JOUR T1 - Short-term plasticity of 7T BOLD ocular dominance and spatial frequency representation in adult human primary visual cortex JF - bioRxiv DO - 10.1101/323741 SP - 323741 AU - Paola Binda AU - Jan W. Kurzawski AU - Claudia Lunghi AU - Laura Biagi AU - Michela Tosetti AU - Maria Concetta Morrone Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/05/16/323741.abstract N2 - Primary visual cortex is considered to be resilient to plastic changes in adults - particularly ocular dominance, which appears to be hard-wired after the end of the critical period. We show that shortterm (2h) monocular deprivation unexpectedly shifts ocular dominance in favor of the deprived eye: contrary to common belief. The plastic response of V1 (measured with 7T fMRI) consists of a homeostatic increase of the deprived-eye BOLD response, a shift of V1 ocular dominance and a decrease of spatial frequency selectivity for the deprived eye. These effects reliably predict the robust perceptual changes induced by deprivation at the individual participant level. Our results indicate that primary visual cortex retains a high potential for homeostatic plasticity in the human adult. ER -