PT - JOURNAL ARTICLE AU - Ray, Subhasis AU - Aldworth, Zane N. AU - Stopfer, Mark A. TI - Feedback inhibition and its control in an insect olfactory circuit AID - 10.1101/624528 DP - 2019 Jan 01 TA - bioRxiv PG - 624528 4099 - http://biorxiv.org/content/early/2019/11/14/624528.short 4100 - http://biorxiv.org/content/early/2019/11/14/624528.full AB - Inhibitory neurons play critical roles in regulating and shaping olfactory responses in vertebrates and invertebrates. In insects, these roles are performed by relatively few neurons, which can be interrogated efficiently, revealing fundamental principles of olfactory coding. Here, with electrophysiological recordings from the locust and a large-scale biophysical model, we analyzed the properties and functions of GGN, a unique giant GABAergic neuron that plays a central role in structuring olfactory codes in the locust mushroom body. Analysis of our in vivo recordings and simulations of our model of the olfactory network suggests that GGN extends the dynamic range of KCs, and leads us to predict the existence of a yet undiscovered olfactory pathway. Our analysis of GGN’s intrinsic properties, inputs, and outputs, in vivo and in silico, reveals basic new features of this critical neuron and the olfactory network that surrounds it.