PT - JOURNAL ARTICLE AU - Sesia, Matteo AU - Katsevich, Eugene AU - Bates, Stephen AU - Candès, Emmanuel AU - Sabatti, Chiara TI - Multi-resolution localization of causal variants across the genome AID - 10.1101/631390 DP - 2019 Jan 01 TA - bioRxiv PG - 631390 4099 - http://biorxiv.org/content/early/2019/11/14/631390.short 4100 - http://biorxiv.org/content/early/2019/11/14/631390.full AB - We present KnockoffZoom, a flexible method for the genetic mapping of complex traits at multiple resolutions. KnockoffZoom localizes causal variants by testing the conditional associations of genetic segments of decreasing width while provably controlling the false discovery rate using artificial genotypes as negative controls. Our method is equally valid for quantitative and binary phenotypes, making no assumptions about their genetic architectures. Instead, we rely on well-established genetic models of linkage disequilibrium. We demonstrate that our method can detect more associations than mixed effects models and achieve fine-mapping precision, at comparable computational cost. Lastly, we apply KnockoffZoom to data from 350k subjects in the UK Biobank and report many new findings.