TY - JOUR T1 - Specific hippocampal interneurons shape consolidation of recognition memory JF - bioRxiv DO - 10.1101/842021 SP - 842021 AU - Jose F. Oliveira da Cruz AU - Arnau Busquets-Garcia AU - Zhe Zhao AU - Marjorie Varilh AU - Gianluca Lavanco AU - Luigi Bellocchio AU - Laurie Robin AU - Astrid Cannich AU - Francisca Julio-Kalajzić AU - Filippo Drago AU - Giovanni Marsicano AU - Edgar Soria-Gomez Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/11/14/842021.abstract N2 - A complex array of different inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically impacts on memory processes is scantly known. We found that a small subclass of type-1 cannabinoid receptor (CB1)-expressing hippocampal interneurons determines episodic-like memory consolidation by linking dopamine D1 receptor signaling to GABAergic transmission.Mice lacking CB1 in D1-positive cells (D1-CB1-KO) displayed impaired long-term, but not short-term, object recognition memory. Re-expression of CB1 in hippocampal, but not striatal, D1-positive cells rescued this memory impairment. Learning induced a facilitation of in vivo hippocampal long-term potentiation (LTP), which was abolished in mutant mice. Chemogenetic and pharmacological experiments revealed that both CB1-mediated memory and associated LTP facilitation involves the local control of GABAergic inhibition in a D1-dependent manner.This study reveals that CB1-/D1-expressing interneurons shape hippocampal circuits to sustain recognition memory, thereby identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral and cognitive outcomes. ER -