TY - JOUR T1 - An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans JF - bioRxiv DO - 10.1101/840363 SP - 840363 AU - Nazish Sayed AU - Tianxiang Gao AU - Robert Tibshirani AU - Trevor Hastie AU - Lu Cui AU - Tatiana Kuznetsova AU - Yael Rosenberg-Hasson AU - Rita Ostan AU - Daniela Monti AU - Benoit Lehallier AU - Shai Shen-Orr AU - Holden T. Maecker AU - Cornelia L. Dekker AU - Tony Wyss-Coray AU - Claudio Franceschi AU - Vladimir Jojic AU - François Haddad AU - José G. Montoya AU - Joseph C. Wu AU - David Furman Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/11/16/840363.abstract N2 - While many diseases of aging have been linked to the immunological system, immune metrics with which to identify the most at-risk individuals are lacking. Here, we studied the blood immunome of 1001 individuals age 8-96 and derived an inflammatory clock of aging (iAge), which tracked with multi-morbidity and immunosenescence. In centenarians, iAge was on average, 40 years lower than their corresponding chronological age. The strongest contributor to this metric was the chemokine CXCL9, which was involved in cardiac aging, affected vascular function, and down-regulated Sirtuin-3, a longevity-associated molecule. Thus, our results identify an important link between inflammatory molecules and pathways known to govern lifespan. ER -