%0 Journal Article %A Satoshi Koyama %A Kaoru Ito %A Chikashi Terao %A Masato Akiyama %A Momoko Horikoshi %A Yukihide Momozawa %A Hiroshi Matsunaga %A Hirotaka Ieki %A Kouichi Ozaki %A Yoshihiro Onouchi %A Atsushi Takahashi %A Seitaro Nomura %A Hiroyuki Morita %A Hiroshi Akazawa %A Changhoon Kim %A Jeong-sun Seo %A Koichiro Higasa %A Motoki Iwasaki %A Taiki Yamaji %A Norie Sawada %A Shoichiro Tsugane %A Teruhide Koyama %A Hiroaki Ikezaki %A Naoyuki Takashima %A Keitaro Tanaka %A Kokichi Arisawa %A Kiyonori Kuriki %A Mariko Naito %A Kenji Wakai %A Shinichiro Suna %A Yasuhiko Sakata %A Hiroshi Sato %A Masatsugu Hori %A Yasushi Sakata %A Koichi Matsuda %A Yoshinori Murakami %A Hiroyuki Aburatani %A Michiaki Kubo %A Fumihiko Matsuda %A Yoichiro Kamatani %A Issei Komuro %T Population-specific and transethnic genome-wide analyses reveal distinct and shared genetic risks of coronary artery disease %D 2019 %R 10.1101/827550 %J bioRxiv %P 827550 %X To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we conducted a large-scale genome-wide association study (GWAS) of 168,228 Japanese (25,892 cases and 142,336 controls) with genotype imputation using a newly developed reference panel of Japanese haplotypes including 1,782 CAD cases and 3,148 controls. We detected 9 novel disease-susceptibility loci and Japanese-specific rare variants contributing to disease severity and increased cardiovascular mortality. We then conducted a transethnic meta-analysis and discovered 37 additional novel loci. Using the result of the meta-analysis, we derived a polygenic risk score (PRS) for CAD, which outperformed those derived from either Japanese or European GWAS. The PRS prioritized risk factors among various clinical parameters and segregated individuals with increased risk of long-term cardiovascular mortality. Our data improves clinical characterization of CAD genetics and suggests the utility of transethnic meta-analysis for PRS derivation in non-European populations. %U https://www.biorxiv.org/content/biorxiv/early/2019/11/16/827550.full.pdf