RT Journal Article
SR Electronic
T1 A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 661728
DO 10.1101/661728
A1 The Tabula Muris Consortium
A1 Angela Oliveira Pisco
A1 Aaron McGeever
A1 Nicholas Schaum
A1 Jim Karkanias
A1 Norma F. Neff
A1 Spyros Darmanis
A1 Tony Wyss-Coray
A1 Stephen R. Quake
YR 2019
UL http://biorxiv.org/content/early/2019/11/18/661728.abstract
AB Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death1. Despite rapid advances over recent years, many of the molecular and cellular processes which underlie progressive loss of healthy physiology are poorly understood2. To gain a better insight into these processes we have created a single cell transcriptomic atlas across the life span of Mus musculus which includes data from 23 tissues and organs. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence3, genomic instability4 and changes in the organism’s immune system2. This Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.