Table S4 Categorization of the complementary metabolites produced in each combination of two symbionts into different metabolic pathways,,,,,,,,,,, ,,,,,,,,,,, ,,,,,,,,,,, ,,,,,,,,,,, Metabolic pathway,Metabolite,KEEG ID,WP,CP,RP,RW,RC,CW,HP,HW,HR Amino acid metabolism (cyteine),S-Glutathionyl-L-cysteine,C05526,0,0,0,1,0,1,0,0,0 Amino sugars and nucleotide sugars,N-Acetyl-D-mannosamine 6-phosphate,C04257,0,0,0,0,0,0,0,0,1 Amino sugars and nucleotide sugars,UDP-N-acetyl-D-mannosamine,C01170,0,0,0,0,0,0,0,0,1 Amino sugars and nucleotide sugars,N-Acetyl-D-mannosamine,C00645,0,0,0,0,0,0,0,0,1 Amino sugars and nucleotide sugars,UDP-N-acetyl-D-galactosamine,C00203,0,0,0,0,0,0,0,0,1 Aminoacyl tRNA,L-Valyl-tRNA,C02554,0,0,1,0,0,0,0,0,0 Aminoacyl tRNA,L-Methionyl-tRNA,C02430,1,1,1,0,0,0,1,0,0 Aminoacyl tRNA,L-Tryptophanyl-tRNA,C03512,1,1,1,0,0,0,1,0,0 Aminoacyl tRNA,L-Lysyl-tRNA,C01931,0,0,0,0,0,0,1,1,0 Aminoacyl tRNA,L-Leucyl-tRNA,C02047,0,0,1,0,0,0,0,0,0 Aminoacyl tRNA,L-Glutamyl-tRNA,C06112,1,0,0,0,0,0,0,1,0 Aminoacyl tRNA (N-formylmethionyl-tRNA),N-Formylmethionyl-tRNA,C03294,1,0,0,0,0,0,1,0,0 Butanoate metabolism,(R)-3-((R)-3-Hydroxybutanoyloxy)butanoate,C04546,0,0,0,0,0,0,0,0,1 Butanoate metabolism,Poly-beta-hydroxybutyrate,C06143,0,0,0,0,0,0,0,0,1 Butanoate metabolism,(R)-3-Hydroxybutanoyl-CoA,C03561,0,0,0,0,0,0,0,0,1 Butanoate metabolism,Acetoacetyl-CoA,C00332,0,0,0,0,0,0,0,0,1 Butanoate metabolism,Acetoacetate,C00164,0,0,0,0,0,0,0,0,1 Carbon metabolism,2-Propylmalate,C05994,0,0,0,0,0,0,1,0,0 Carbon metabolism,Carbonic acid,C01353,0,0,0,0,0,0,0,1,1 Carbon metabolism,alpha-D-Glucose,C00267,0,0,0,0,0,0,1,0,0 L-Isoleucine,L-Leucine,C00123,0,0,1,0,0,0,0,0,0 L-Valine,L-Valine,C00183,0,0,1,0,0,0,0,0,0 Leucine metabolism,3-Methylbutyraldehyde oxime,C17255,0,0,1,0,0,0,0,0,0 Lysine biosynthesis (not lysine),"meso-2,6-Diaminoheptanedioate",C00680,0,1,1,0,0,0,1,0,0 Lysine metabolism,N6-Acetyl-L-lysine,C02727,0,0,0,0,0,0,1,1,0 Lysine metabolism (lysine),L-Isoleucine,C00407,0,0,1,0,0,0,0,0,0 NC,Precorrin 1,C15527,0,0,0,0,0,0,0,1,0 NC,3-Deoxy-D-manno-octulosonate 8-phosphate,C04478,0,0,0,1,0,0,0,0,0 NC,L-Threonylcarbamoyladenylate,C20641,0,0,1,1,0,0,0,0,0 Nicotinate & nicatinamide metabolism (cofactors),Nicotinamide-beta-riboside,C03150,0,0,0,0,0,0,0,1,0 Nucleotide metabolism,Cytidine,C00475,0,0,0,1,0,0,0,1,0 Potential thiamine precursor/purine metabolism,1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate,C04751,1,0,0,0,0,0,1,0,0 SM,Precorrin 2,C02463,0,0,0,0,0,0,0,1,0 SM,tRNA containing 6-isopentenyladenosine,C04432,0,0,0,1,1,0,0,1,1 Terpenoid/sm,2-Octaprenylphenol,C05810,0,0,0,0,0,0,0,1,1 Terpenoid/sm,"2-C-Methyl-D-erythritol 2,4-cyclodiphosphate",C11453,0,0,0,0,0,0,0,1,0 Terpenoid/sm,"di-trans,poly-cis-Hexaprenyl diphosphate",C17434,0,1,0,0,0,0,0,0,0 Terpenoid/sm,"trans,trans-Farnesyl diphosphate",C00448,0,1,0,0,0,0,0,0,0 Terpenoid/sm,Dimethylallyl diphosphate,C00235,0,0,0,0,0,0,0,1,0 Terpenoid/sm,"di-trans,poly-cis-Heptaprenyl diphosphate",C17436,0,1,0,0,0,0,0,0,0 Terpenoid/sm,"di-trans,poly-cis-Octaprenyl diphosphate",C17437,0,1,0,0,0,0,0,0,0 Terpenoid/sm,"di-trans,poly-cis-Pentaprenyl diphosphate",C17435,0,1,0,0,0,0,0,0,0 Terpenoid/sm,1-Hydroxy-2-methyl-2-butenyl 4-diphosphate,C11811,0,0,0,0,0,0,0,1,0 Terpenoid/sm,2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol,C11436,0,0,0,0,0,0,0,1,0 Terpenoid/sm,Isopentenyl diphosphate,C00129,0,1,0,0,0,0,0,0,0 Terpenoid/sm,"di-trans,poly-cis-Decaprenyl diphosphate",C04509,0,1,0,0,0,0,0,0,0 Terpenoid/sm,2-C-Methyl-D-erythritol 4-phosphate,C11434,0,0,0,0,0,0,0,1,0 ,D-Arabinose 5-phosphate,C01112,0,0,0,1,0,0,0,0,0 ,5-Methyltetrahydrofolate,C00440,1,1,1,0,0,0,1,0,0 ,2-Oxobutanoate,C00109,0,0,0,1,0,0,0,0,1 ,5-Amino-4-imidazolecarboxyamide,C04051,0,0,0,0,0,0,1,0,0 ,L-Isoleucyl-tRNA(Ile),C03127,0,0,1,0,0,0,0,0,0