Supplementary Table 5. Detailed clinical information on persistent an nonpersistent isolates,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,MIC,,,,Treatment,,,,,,,,,,,,Catheter information,,,,,,,,,,,,,,,,,,,,,,,,,,,
Group,Protocol number,Strain ID,Species,Isolation Day,AMB,FCZ,VCZ,CAS,Previous antifungal,First day,Last Day,Treat-1,First Day,Last Day,Treat-2,First Day,Last Day,Treat-3,First Day,Last day,CVC ,Cateter out data,Neutropenia,Gender,Coexisting exposure,Age (years),Corticosteroid treatment,Chemoterapy,Survival 30d,,,,,,,,,,,,,,,,,,,
Nonpersistent,04-020-01,7111A,C. albicans,25/10/10,0.5,0.125,0.03,0.03,no,-,-,FCZ,30/10/10,26/11/10,no,-,-,no,-,-,Yes,10/30/10,no,F,surgery/antibiotic treatment,79,no,no,yes,,,,,,,,,,,,,,,,,,,
,04-033-01,7415,C. albicans,18/12/10,0.25,0.125,0.03,0.03,no,-,-,FCZ,23/12/10,30/12/10,no,-,-,no,-,-,Yes,12/23/10,no,F,cardiac disease,80,no,no,yes,,,,,,,,,,,,,,,,,,,
,04-037-01,7419,C. albicans,23/12/10,0.25,0.125,0.03,0.03,no,-,-,FCZ,26/12/10,09/01/11,no,-,-,no,-,-,Yes,1/9/11,no,F,cardiac disease,81,no,no,yes,,,,,,,,,,,,,,,,,,,
,04-038-01,7420,C. albicans,01/01/11,0.25,0.125,0.03,0.03,no,-,-,FCZ,05/01/11,20/01/11,no,-,-,no,-,-,Yes,1/2/11,no,M,surgery/antibiotic treatment,43,no,no,yes,,,,,,,,,,,,,,,,,,,
,04-051-01,7561,C. albicans,22/02/11,0.5,0.125,0.03,0.03,no,-,-,FCZ,22/02/11,28/02/11,CAS,2/28/11,3/2/11,CAS,3/2/11,3/6/11,Yes,2/25/11,no,M,cardiac disease,75,no,no,no,,,,,,,,,,,,,,,,,,,
,01-034-01,7752A,C. albicans,04/04/11,0.5,0.5,0.06,0.06,no,-,-,FCZ,08/04/11,22/04/11,no,-,-,no,-,-,Yes,4/8/11,no,F,cardiac disease,76,no,no,yes,,,,,,,,,,,,,,,,,,,
,07-015-01,7885,C. albicans,16/05/11,0.5,0.5,0.03,0.03,no,-,-,FCZ,18/05/11,31/05/11,no,-,-,no,-,-,Yes,5/14/11,no,M,surgery/antibiotic treatment,48,no,no,yes,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S01,-,1-7794A,C. albicans,2011.04.19,0.125,0.125,,0.0625,no,-,-,FCZ,2011.04.22,2011.05.09,no,-,-,no,-,-,Yes,2011.04.29,no,F,cancer,63,yes,no,no,,,,,,,,,,,,,,,,,,,
,-,1-7794B,C. albicans,2011.04.24,0.125,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,1-7794D,C. albicans,2011.04.25,0.125,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,1-7794E,C. albicans,2011.05.02,0.0625,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,1-7796A,C. albicans,2011.05.04,0.125,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,1-7796B,C. albicans,2011.05.04,0.5,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S02,-,6-7063A,C. albicans,2010.11.19,0.0625,0.125,,0.0625,no,-,-,FCZ,2010.11.23,2010.11.24,CAS,2010.11.24,2010.11.30,FCZ,2010.12.01,2010.12.05,Yes,2010.11.22,no,M,cancer/cardiac disease,64,yes,no,no,,,,,,,,,,,,,,,,,,,
,-,6-7063B,C. albicans,2010.11.19,0.125,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,6-7071D,C. albicans,2010.11.23,0.125,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,6-7071A,C. albicans,2010.11.23,0.125,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,6-7071B,C. albicans,2010.11.25,0.125,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,6-7071C,C. albicans,2010.11.25,0.125,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,6-7073,C. albicans,2010.11.29,0.125,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,6-7145C,C. albicans,2010.12.01,0.25,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,6-7145B,C. albicans,2010.12.01,0.25,0.125,,0.0625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S03,-,9268A,C. albicans,20.02.13,0.03,1.0,0.03,0.03,no,-,-,FCZ,2/27/13,Unknown,AMB,3/20/17,Unknown,no,*,*,yes,25.02.13 - 19.03.13,no,F,surgery/antibiotic treatment,47,no,no,no,,,,,,,,,,,,,,,,,,,
,-,9268B,C. albicans,12.03.13,0.03,0.5,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,9268C,C. albicans,12.03.13,0.03,1.0,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,9268D,C. albicans,12.03.13,0.03,0.5,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,9268E,C. albicans,20.03.13,0.03,0.5,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,9268F,C. albicans,20.03.13,0.03,0.5,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,9268G,C. albicans,20.03.13,0.03,0.5,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,-,9268H,C. albicans,22.03.13,0.125,˃64,˃16,0.25,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S04,02-044-01-01,7801A,C. albicans,09.05.11,0.5,0.25,0.03,0.03,no,-,-,FCZ,6/11/11,8/10/11,no,-,-,-,-,-,yes,5/11/11,no,F,surgery/antibiotic treatment,78,no,no,yes,,,,,,,,,,,,,,,,,,,
,02-044-01-02,7801B,C. albicans,09.05.11,0.5,0.25,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,02-044-01-03,7801C,C. albicans,11.05.11,0.5,0.25,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,02-044-01-04,7801D,C. albicans,11.05.11,0.5,0.25,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,02-044-01-05,7868,C. albicans,02.06.11,0.5,0.25,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S05,05-0046-01-01,7896A,C. albicans,12/18/03,0.125,0.25,0.03,0.03,,,,FCZ,18.12.2003,02.01.2004,-,-,-,-,-,-,yes,ignored,no,F,surgery/antibiotic treatment,54,no,no,no,,,,,,,,,,,,,,,,,,,
,05-0046-01-02,7896B,C. albicans,12/29/03,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,05-0046-01-03,7896C,C. albicans,12/31/03,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,05-0046-01-04,7896D,C. albicans,1/7/04,0.5,0.125,0.06,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S06,01-005-01-01,6829A,C. albicans,8/22/10,0.5,0.25,0.03,0.03,no,-,-,FCZ,8/23/10,9/22/10,-,-,-,-,-,-,yes,8/27/10,no,M,cardiac disease,47,no,no,yes,,,,,,,,,,,,,,,,,,,
,01-005-01-02,6829B,C. albicans,8/22/10,0.5,0.25,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,01-005-01-03,6829C,C. albicans,8/28/10,0.5,0.25,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,01-005-01-04,6829D,C. albicans,9/2/10,0.5,0.25,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S07,02-057-01-01,7986A,C. albicans,7/2/11,0.5,0.125,0.03,0.03,no,-,-,FCZ,7/13/11,7/31/11,-,-,-,-,-,-,yes,7/11/11,no,F,pulmonary disease,44,no,no,yes,,,,,,,,,,,,,,,,,,,
,02-057-01-02,7986B,C. albicans,7/12/11,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,02-057-01-03,7986C,C. albicans,7/15/11,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,02-057-01-04,7986D,C. albicans,7/16/11,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,02-057-01-05,7986E,C. albicans,7/16/11,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S08,04-013-01-01,7101,C. albicans,10/21/10,0.5,1,0.03,0.06,no,-,-,FCZ,10/21/10,11/6/10,-,-,-,-,-,-,yes,10/20/10,no,F,cardiac disease,80,no,no,yes,,,,,,,,,,,,,,,,,,,
,04-013-01-02,7107A,C. albicans,11/6/10,0.5,1,0.03,0.06,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,04-013-01-03,7107B,C. albicans,11/19/10,0.5,1,0.03,0.06,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S09,32-071-01-01,10319,C. albicans,12/1/05,0.5,0.125,0.03,0.03,no,-,-,FCZ,12/5/05,12/7/05,-,-,-,-,-,-,yes,,no,F,cardiac disease,69,no,no,no,,,,,,,,,,,,,,,,,,,
,32-071-01-02,,C. albicans,12/3/05,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,32-071-01-03,,C. albicans,12/5/05,1.0,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S10,32-089-01-01,193,C. albicans,2/9/06,1,0.25,0.03,0.03,no,-,-,FCZ,2/13/06,2/15/06,-,-,-,-,-,-,yes,,no,M,solid cancer,78,no,no,no,,,,,,,,,,,,,,,,,,,
,32-089-01-02,261,C. albicans,2/13/06,1,0.25,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S11,32-041-1-1,5436A,C. albicans,5/25/09,0.5,0.125,0.03,0.03,FCZ,5/17/09,-,FCZ,5/25/09,6/3/09,AMB,6/4/09,6/25/09,-,-,-,5/19/09,6/6/09,no,M,abdominal surgery,6,no,no,yes,,,,,,,,,,,,,,,,,,,
,32-041-1-2,5436B,C. albicans,6/2/09,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,32-041-1-3,5436C,C. albicans,6/5/09,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,32-041-1-4,5436D,C. albicans,6/9/09,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Persistent S12,33-010-1-1,5605A,C. albicans,7/20/09,0.5,0.125,0.03,0.03,no,-,-,FCZ,7/21/09,7/1/09,-,-,-,-,-,-,7/9/09,,no,F,solid cancer/cardiac disease,87,no,no,no,,,,,,,,,,,,,,,,,,,
,33-010-1-2,5605B,C. albicans,7/23/09,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
,33-010-1-3,5605C,C. albicans,7/31/09,0.5,0.125,0.03,0.03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,