Figure 1. Spatial correlation between recombination rate, TADs/LADs and isochores.

(A) The heat map of chromatin interactions in mouse chromosome 17 (from Jung et al. 2017) is aligned to the recombination profile from Morgan et al. and to the corresponding compositional profile drawn from mm10 genome assembly, using a sliding window of 300 Kb. Increasing GC levels are represented in different colours, deep blue, light blue, yellow, orange and red, respectively; the multi-coloured vertical bars on the top right indicate GC levels that correspond to the compositional boundaries among isochore families. Blue line delimits GC-poor isochores and broken black lines indicate cold spots (in grey), very similar results are obtained with ES cells Hi-C interaction matrices (Figure S1). (B) GC histogram of embryonic stem cells TADs from Dixon et al. (top) and cold spots intervals (bottom) defined in Morgan al.2017.